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Panel recommends third vaccine doses for People in danger

Close-up of the Moderna vaccine at the Park County Health Department’s COVID-19 Vaccination Clinic for Seniors 80+ on January 28, 2021 in Livingston, Montana.

William Campbell | Getty Images

A key panel at the Centers for Disease Control and Prevention unanimously voted on Friday to recommend booster shots of the Pfizer or Moderna Covid-19 vaccines to immunocompromised Americans, clearing a major hurdle that allows vulnerable patients to receive a third dose Receive.

The decision of the Advisory Committee on Immunization Practices follows the approval of the booster vaccination for immunocompromised patients by the Food and Drug Administration on Thursday. The CDC, which has the final say, is expected to adopt the panel’s recommendation later on Friday. With the OK from both authorities, the booster doses could be given immediately.

“For the past almost a year and a half, I have cared for many patients with life-threatening and fatal diseases, and even post-vaccination,” who are immunocompromised, Dr. Camille Nelson Kotton, a transplant and infectious disease specialist at Massachusetts General Hospital, told the panel to strongly support boosters for those with weak immune systems. “They just suffer from a lack of good vaccination protection, we know that the effectiveness of the vaccine is diminished in this population.”

The FDA approved third doses of Pfizer and Moderna vaccines for “solid organ transplant recipients or those diagnosed with conditions considered to be equivalent”. Authorities have not released any booster vaccinations to anyone else fully vaccinated or to recipients of Johnson & Johnson’s vaccine, which is manufactured in the Janssen vaccines division.

“There is currently no data to support the use of an additional dose of mRNA COVID-19 vaccine after a Janssen Covid-19 primary vaccine in immunocompromised people. The FDA and CDC are actively working to provide guidance on this matter,” said Dr . Neela. from CDC Goswami wrote to ACIP in her presentation.

The CDC recommended a third dose for at-risk Americans 28 days or more after completing the first two rounds of shooting. Booster doses are also recommended for cancer patients and HIV patients after data showed that immune responses after the first two doses did not provide adequate protection against Covid-19 and its variants in these patients.

The additional recordings were recommended for Pfizer recipients aged 12 and over and for Moderna recipients aged 18 and over. The panel said it will revisit the recordings for younger Moderna recipients after the FDA clears the recordings for children.

Immunocompromised patients make up approximately 2.7% of the US adult population and 44% of breakthrough hospital-treated infections that someone will become infected even after being fully vaccinated.

Studies suggest that a third dose of vaccine might help people whose immune systems do not respond as well to a first or second dose. Five small studies cited by the CDC showed that 11% to 80% of people with compromised immune systems had no detectable antibodies to Covid after two shots.

Among immunocompromised patients who had no detectable antibody response, 33 to 50% developed an antibody response after receiving an additional dose, according to the CDC.

Patients at risk are also more likely to experience persistent Covid infections, the panel said. The data also suggests that they are likely to shed more viruses and potentially infect more people than those who are not immunocompromised.

Early data from small studies on the effects of booster doses in immunocompromised patients showed no serious side effects from a third vaccination with an mRNA vaccine and symptoms beyond those identified after the first two-dose dose.

Several countries, including Israel, the Dominican Republic, France, the UK and Germany, have either already started or are considering giving booster doses of Covid-19 vaccines.

Immunocompromised patients receiving a third dose should continue to wear a mask and social distancing, the panel said.

Survey data from hesitant immunocompromised patients show that, according to a panel presentation by Dr. Kathleen Dooling of the CDC still has many concerned about the side effects of the vaccines and the speed at which the vaccines have been developed, as well as the general suspicion about the vaccines.

About 10% of immunocompromised patients say they will “definitely not” receive a vaccine, another 9% say they are “unsure” or “probably not” will get a vaccine, and 44% say they will “definitely” get a vaccine Vaccine to be obtained. Those who are hesitant are usually younger, belong to an ethnic or racial minority, or are female.

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